Senescent cells talk frankly with their neighbors
نویسندگان
چکیده
منابع مشابه
Microbial Interactions: Bacteria Talk to (Some of) Their Neighbors
A recent study reports that Bacillus subtilis biofilm formation depends upon paracrine signaling where the signal-producing and target-responsive cells are different.
متن کاملSocializing with the Neighbors Stem Cells and Their Niche
The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so, it is essential to understand how stem cells interact with their microenvironment, the so-called stem cell niche, to establish and maintain their properties. In this review, we examine adult stem cel...
متن کاملSenescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This response, termed cellular senescence, is controlled by the p53 and RB tumor suppressor proteins and constitutes a potent anticancer mechanism. Nonetheless, senescent cells ac...
متن کاملB cells talk to their progenitors.
Aging is associated with alterations in the B-cell compartment resulting from decreased production of these important cells. However, despite this decline in B lymphopoiesis, absolute numbers of B cells remain unchanged in peripheral blood, spleen, and lymph nodes during aging.2,3 Published studies have clearly shown that this defective production of B cells is linked in part to acquired hemato...
متن کاملWhen cells tell their neighbors which direction to divide.
Many cells must divide in specific orientations, yet for only a handful of cases do we have some understanding of how cells choose division orientations. We know of only a few cases where division orientations are controlled by specific cell-cell interactions. These cases are of interest, because they tell us something new and seemingly fundamental about how cells can function during developmen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2015
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2015.1056608